Mucosal T Lymphocytes and Lymphocytes Migration. Library of Congress subject headings for this publication: Mucous membrane Immunology Congresses, Mucous Membrane immunology congresses. Notes Expanded and reviewed papers presented at the 8th International Congress of Mucosal Immunology. Includes bibliographical references and index. View online Borrow Buy Freely available Show 0 more links Related resource Publisher description at http: Set up My libraries How do I set up "My libraries"? These 7 locations in All: Open to the public ; Flinders University Central Library.
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Very few cells were dendriform in shape. Previous experiments have demonstrated that mucosal immunization significantly enhances the ability of rats and mice to clear NTHI from the lungs compared with the nonimmune animals 18 , It had previously been established that the rat and mouse models followed similar patterns in relation to bacterial clearance following pulmonary challenge with NTHI data not included. Clearance of bacteria from the lungs has been found to be a complex interaction of events. The experimental model used in this study focuses on the clearance of bacteria from the lung and compares immunized to nonimmune animals.
The model has been well established for the study of immune mechanisms of bacterial clearance from the lung, and kinetic studies have demonstrated marked differences in cellular infiltration into the lung tissues of immunized and nonimmunized animals after challenge with NTHI 19 , The expression of MHC-I would be of interest to determine the upregulation and use of this pathway for antigen presentation. Both macrophages 37 , 43 and bacterially stimulated intestinal epithelial cells 1 , 2 have been shown to act as antigen-presenting cells via the MHC-I pathway.
Mucosal Surfaces: Immunological Protection
This would be beneficial in optimizing the levels of IgA at the mucosal surface The levels of MHC-II expression continued to rise until live bacteria had been eliminated from the lung. Previous work on respiratory tract infection with Moraxella catarrhalis had demonstrated the importance of dendritic cell infiltration along the length of the trachea following bacterial challenge However, the majority of cells showing MHC-II expression in the bronchi and alveolar sacs of immunized animals following pulmonary challenge with NTHI also stained positively for B-cell markers.
While there is evidence that dendritic cells are extremely important in their surveillance role in the respiratory tract 22 and while in vitro they are more efficient at antigen presentation to T cells than macrophages, their ability to uptake and present antigen without macrophage help is minimal 21 , The relationship between dendritic cells and macrophages is complex, with small numbers of lung interstitial macrophages enhancing the ability of dendritic cells to act as antigen-presenting cells, whereas large numbers of macrophages have an inhibitory effect on the process For this reason, the MHC-II recruitment observed in this model may be a demonstration that it is more effective for the respiratory tract to recruit different groups of antigen-presenting cells to separate but interconnecting locations in order to maximize their antigen-processing potential.
It is thought that these T cells play an important role in enhancing the clearance of bacteria in immune compared to nonimmune rats through both innate 8 and acquired 13 mechanisms. Interestingly, T-cell transfer experiments from immunized to naive mice have also been shown to enhance innate mechanisms such as the recruitment and activation of macrophages and polymorphs to the site of challenge in experiments involving L.
Essentials of Mucosal Immunology
Kinetic studies on the influx of cells to the lungs of animals challenged with NTHI have shown an enhancement of cell numbers in immune compared with nonimmune animals over time. We thank Rosario Rosaria and Capital Pathology for advice and help in the immunohistological techniques.
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luvokabahuma.tk: Essentials of Mucosal Immunology: Martin F. Kagnoff, Hiroshi Kiyono
Microbial Immunity and Vaccines. Ruth Foxwell , Jennelle M. Kyd , Guna Karupiah , Allan W. ABSTRACT A rodent respiratory experimental model has proved useful for investigating the immune mechanisms responsible for clearance of bacteria from the lungs.
View inline View popup. Returned for modification 10 November Accepted 2 January One size fits all: San Diego, Calif , pp 85 — University of Canberra , Canberra, Australia.